Enhanced cellular uptake of engineered spider silk particles
نویسندگان
چکیده
منابع مشابه
Enhanced cellular uptake of engineered spider silk particles.
Drug delivery systems allow tissue/cell specific targeting of drugs in order to reduce total drug amounts administered to an organism and potential side effects upon systemic drug delivery. Most drug delivery systems are polymer-based, but the number of possible materials is limited since many commercially available polymers induce allergic or inflammatory responses or lack either biodegradabil...
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Materials based on biodegradable polyesters such as poly(butylene terephthalate) (PBT) 20 or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT) have potential 21 application as pro-regenerative scaffolds for bone tissue engineering. Herein is reported the 22 preparation of films composed of PBT or PBTAT and an engineered spider silk protein, 23 (eADF4(C16)), that displa...
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In applications such as flavor encapsulation, drug delivery, and biomedical devices, microencapsulation is developing into an increasingly effective method for the protection and delivery of active ingredients. Herein, we show that spider-silk proteins are well-suited for producing responsive microcapsules with high mechanical stability. Emulsion interfaces are harnessed to induce the controlle...
متن کاملEngineered spider silk protein-based composites for drug delivery.
Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. ...
متن کاملSpider Silk
Some things about spider silk are difficult to understand.The genetic code for one of the more perplexing types of silk—the strands spiders use to weave their egg cases. Each case must be tough enough to keep out parasites, impermeable to rain and fungus, and breathable while insulating eggs from temperature extremes. These qualities alone would make an impressive fabric.The egg cases may even ...
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ژورنال
عنوان ژورنال: Biomaterials Science
سال: 2015
ISSN: 2047-4830,2047-4849
DOI: 10.1039/c4bm00401a